我们的大脑如何处理垃圾呢

　　\u6700\u8fd1\uff0c\u5783\u573e\u5206\u7c7b\u5df2\u7ecf\u6210\u4e86\u70ed\u70b9\u8bdd\u9898\uff0c\u4f46\u5b9e\u884c\u8fd9\u4e00\u4e3e\u63aa\u7684\u6700\u7ec8\u76ee\u7684\u8fd8\u662f\u4e3a\u4e86\u4fdd\u62a4\u6211\u4eec\u8d56\u4ee5\u751f\u5b58\u7684\u5730\u7403\u73af\u5883\u3002\u540c\u6837\uff0c\u5927\u8111\u4e3a\u4e86\u7ef4\u6301\u5065\u5eb7\uff0c\u4e5f\u4e13\u95e8\u6709\u4e00\u5957\u81ea\u5df1\u7684\u201c\u5783\u573e\u6e05\u9664\u7cfb\u7edf\u201d\uff0c\u5373glymphatic\uff08\u7c7b\u6dcb\u5df4\uff09\u7cfb\u7edf\u3002\u5b83\u6709\u5f88\u591a\u529f\u80fd\uff0c\u800c\u4e14\u5f88\u591a\u75be\u75c5\u4e5f\u90fd\u4e0e\u5b83\u76f8\u5173\u3002\u4f46\u662f\uff0c\u7531\u5927\u8111\u548c\u810a\u9ad3\u7ec4\u6210\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf(CNS)\u5e76\u4e0d\u5b58\u5728\u771f\u6b63\u7684\u6dcb\u5df4\u7ba1\u3002\u7531\u4e8eCNS\u662f\u9ad8\u5ea6\u6d3b\u8dc3\u7684\uff0c\u6240\u4ee5\u5e9f\u7269\u53ef\u4ee5\u8fc5\u901f\u79ef\u7d2f\u3002CNS\u5bf9\u5468\u56f4\u73af\u5883\u7684\u6ce2\u52a8\u4e5f\u975e\u5e38\u654f\u611f\uff0c\u6240\u4ee5\u8eab\u4f53\u9700\u8981\u4ee5\u67d0\u79cd\u65b9\u5f0f\u6e05\u9664\u7ec6\u80de\u5783\u573e\uff0c\u8fd9\u5c31\u662fglymphatic\u7cfb\u7edf\u53d1\u6325\u4f5c\u7528\u7684\u65f6\u5019\u3002\u5728\u8fd9\u79cd\u57fa\u4e8e\u5927\u8111\u7684\u5783\u573e\u5904\u7406\u7cfb\u7edf\u88ab\u53d1\u73b0\u4ee5\u524d\uff0c\u79d1\u5b66\u5bb6\u4eec\u8ba4\u4e3a\u6bcf\u4e2a\u7ec6\u80de\u90fd\u80fd\u5904\u7406\u81ea\u5df1\u7684\u4ee3\u8c22\u5e9f\u7269\u3002\u53ea\u662f\u968f\u7740\u6211\u4eec\u7684\u5e74\u9f84\u589e\u957f\uff0c\u7ec6\u80de\u7cfb\u7edf\u8d85\u8f7d\u6216\u53d8\u6162\uff0c\u7ec6\u80de\u95f4\u7684\u4ee3\u8c22\u5783\u573e\u548c\u6709\u5bb3\u7269\u5c31\u4f1a\u79ef\u805a\uff0c\u5176\u4e2d\u5c31\u5305\u62ec\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u76f8\u5173\u7684\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u3002\u661f\u5f62\u80f6\u8d28\u7ec6\u80de

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　　Nedergaard\u548c\u5979\u7684\u56e2\u961f\u53d1\u73b0\uff0cglymphatic\u7cfb\u7edf\u5728\u52a8\u7269\u7761\u7720\u671f\u95f4\u662f\u6700\u6d3b\u8dc3\u7684\u3002\u5f53\u5c0f\u9f20\u7761\u89c9\u65f6\uff0c\u95f4\u9699\u7684\u4f53\u79ef\u589e\u52a0\u4e8660%\u3002\u540c\u65f6\uff0c\u8fd9\u4e5f\u4fc3\u8fdb\u4e86CSF\u548c\u95f4\u8d28\u6db2\u4e4b\u95f4\u7684\u4ea4\u6362\uff0c\u52a0\u901f\u4e86\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u6e05\u9664\u3002\u4ed6\u4eec\u603b\u7ed3\u9053\uff1a\u201c\u7761\u7720\u7684\u6062\u590d\u529f\u80fd\u53ef\u80fd\u662f\u589e\u5f3a\u6e05\u9664\u6e05\u9192\u72b6\u6001\u4e0b\u79ef\u805a\u5728CNS\u4e2d\u6f5c\u5728\u795e\u7ecf\u6bd2\u6027\u5e9f\u7269\u7684\u7ed3\u679c\u3002\u201d\u8fd9\u9879\u65e9\u671f\u7684\u7814\u7a76\u5f15\u53d1\u4e86\u4e00\u6ce2\u65b0\u7684\u7814\u7a76\u6d6a\u6f6e\uff0c\u8be5\u56e2\u961f\u6700\u8fd1\u4e00\u9879\u7814\u7a76\u63ed\u793a\u4e86\u9ad8\u8840\u538b\u5bf9glymphatic\u7cfb\u7edf\u529f\u80fd\u7684\u5f71\u54cd\u3002\u7814\u7a76\u7ed3\u679c\u8fd1\u65e5\u5df2\u53d1\u8868\u5728\u300aJNeurosci\u300b\u4e0a\u3002

　　\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u9ad8\u8840\u538b\u4f1a\u4f7f\u8840\u7ba1\u5931\u53bb\u5f39\u6027\uff0c\u53d8\u5f97\u8d8a\u53d1\u50f5\u786c\u3002\u7531\u4e8e\u52a8\u8109\u58c1\u6709\u89c4\u5f8b\u7684\u8109\u52a8\u9a71\u52a8\u7740glymphatic\u7cfb\u7edf\uff0c\u786c\u5316\u5219\u963b\u788d\u4e86\u5176\u529f\u80fd\u3002\u5229\u7528\u9ad8\u8840\u538b\u5c0f\u9f20\u6a21\u578b\uff0c\u8be5\u7814\u7a76\u56e2\u961f\u53d1\u73b0\uff0c\u9ad8\u8840\u538b\u5f15\u8d77\u7684\u52a8\u8109\u786c\u5316\u786e\u5b9e\u5e72\u6270\u4e86\u5783\u573e\u5904\u7406\u7cfb\u7edf\u7684\u5de5\u4f5c\u65b9\u5f0f\uff0c\u963b\u6b62\u4e86\u8be5\u7cfb\u7edf\u6709\u6548\u6e05\u7406\u5927\u8111\u4e2d\u7684\u5927\u5206\u5b50\uff0c\u5982\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u3002\u8fd9\u4e00\u53d1\u73b0\u53ef\u80fd\u6709\u52a9\u4e8e\u89e3\u91ca\u4e3a\u4ec0\u4e48\u9ad8\u8840\u538b\u3001\u8ba4\u77e5\u8870\u9000\u4e0e\u75f4\u5446\u75c7\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\u3002\u5e15\u91d1\u68ee\u75c7\u662f\u53e6\u4e00\u79cd\u4e0e\u5927\u8111\u4e2d\u86cb\u767d\u8d28\u79ef\u805a\u4e3a\u7279\u5f81\u7684\u75be\u75c5\uff0c\u8be5\u86cb\u767d\u8d28\u662f\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u3002\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u4e5f\u56e0\u6b64\u6000\u7591\u5176\u662f\u5426\u4e5f\u6d89\u53caglymphatic\u7cfb\u7edf\u3002\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\uff0c\u5927\u8111\u7684\u591a\u5df4\u80fa\u901a\u8def\u53d7\u5230\u5e72\u6270\u3002\u8fd9\u4e9b\u901a\u8def\u5728\u7761\u7720-\u89c9\u9192\u5468\u671f\u548c\u663c\u591c\u8282\u5f8b\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5e15\u91d1\u68ee\u60a3\u8005\u7ecf\u5e38\u51fa\u73b0\u7761\u7720\u7d0a\u4e71\u7684\u60c5\u51b5\u3002\u8fd1\u65e5\u53d1\u8868\u5728\u300aNeuroscience & Biobehavioral 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0===n&&(h=e),t.resolve(e)):t.reject({errno:999999,errmsg:无法获取登录状态}),t.promise()},e.getConfig(ignoreCookie)?o.get():i&&e.utils.getCookie(Q)?o.get(o.getDomainApi(i)):e.utils.getCookie(Q)?o.get(o.getDomainApi(n)):a.Deferred().reject(e.ERROR.NOT_SIGNED_IN).promise()},getUserSecInfo:function(e){var t=new c({crumb:e});return t.get(t.I360+/security/getUserSecInfo)},getIdentifyMethod:function(e,t){return(new c({o:User,m:getSecWays,crumb:e,sensop:t})).post()},getCaptchaUrl:function(t){var n=e.getConfig(captchaAppId,i360),r=new c({captchaScene:t,captchaApp:n});return r.get(r.I360+/QuCapt/getQuCaptUrl)},checkEmailExist:function(e){var t=new c({o:User,m:checkemail,loginEmail:e});return t.done=s(202),t.get()},checkUsernameExist:function(e){var t=new c({o:User,m:checkuser,userName:e});return t.done=s(1e4),t.get()},checkNicknameExist:function(e){var t=new c({o:User,m:checknickname,nickName:e});return t.done=s(259),t.get()},checkMobileNumberExist:function(e,t,n){var e=t?t+e:e;return n=n,(new c({o:User,m:checkmobile,mobile:e,type:n})).post()},checkEmailStatus:function(e){var t=new c({crumb:e});return t.get(t.I360+/active/checkLoginEmailStatus)},getMobileState:function(){return(new c({o:user,m:getStateList,quc_lang:})).get()},checkMobileLogin:function(e){return(new c({o:user,m:checkLoginMethod,acctype:2,lm:1,account:e})).get()},checkSignUpCaptchaRequired:function(){var t=new c({captchaApp:e.getConfig(captchaAppId,i360)});return t.get(t.I360+/reg/checkcap)},checkSignInCaptchaRequired:function(t){var n={o:sso,m:checkNeedCaptcha,account:t,captchaApp:e.getConfig(captchaAppId,i360)};return(new c(n)).get()},identify:function(e,t,n,i,s){var o={o:User,m:checkSecWay,crumb:e,vtype:n,sensop:t};returnpwd==n&&(i=r(i),o.captcha=s),o.vc=i,(new c(o,{},!0)).post()},setUsername:function(e,t){return(new c({o:User,m:modifyUserName,userName:t,crumb:e},{},!0)).post().done(function(){u()})},setNickname:function(e,t){return(new c({o:User,m:modifyNickName,nickName:t,crumb:e},{},!0)).post().done(function(){u()})},setEmail:function(e,t){var n=new c({crumb:e,loginEmail:t},{},!0);return n.post(n.I360+/active/doSetLoginEmail).done(function(){u()})},setSecEmail:function(e,t){var n=new c({crumb:e,secemail:t},{},!0);return n.post(n.I360+/profile/dosetsecemail).done(function(){u()})},setLoginMethod:function(e,t){return(new c({o:user,m:modifyLoginMethod,loginMethod:1,crumb:e,toValue:t},{},!0)).post().done(function(){u()})},setCookie:function(t,n){var r=e.getConfig(supportHttps,l),i=https==e.getConfig(protocol,null).toLowerCase();t=decodeURIComponent(t),void 0===n?n=e.getConfig(domainList,[]):a.isArray(n)(n=[n]);var s,o=[];return a.each(n,function(e,n){a.inArray(n,r)-1?(s=new c({o:sso,m:setcookie,s:t},{jsonp:func},!0),o.push(s.get(s.getDomainApi(n)))):i(s=new c({o:sso,m:setcookie,s:t},{jsonp:func}),o.push(s.get(s.getDomainApi(n))))}),a.when.apply(a,o)},sendSmsTokenNeedPhrase:function(e,t,n,r,i,s){var o=;returnboolean==typeof e&&(n=t,t=e,r=n,i=r,e=null),login==s?o=0:reg==s&&(o=2),(new c({o:User,m:sendSmsCodeNew,condition:t?1:2,account:n,crumb:e,sms_scene:o,captcha:r,vt:i})).post()},sendSmsToken:function(e,t,n,r){var i=;returnboolean==typeof e&&(n=t,t=e,e=null),object==typeof n&&(n=n.areaCode+n.mobileNumber),findpwd==r&&(i=1),(new c({o:User,m:sendSmsCode,condition:t?1:2,account:n,crumb:e,sms_scene:i})).post()},sendEmailToken:function(e,t){return(new c({o:User,m:sendEmsCode,condition:1,crumb:e,vtype:t})).post()},sendActivationEmail:function(e){var t=new c({crumb:e});return t.post(t.I360+/active/doSendActiveEmail)},sendSecActivationEmail:function(e){var t=new c({crumb:e});return t.post(t.I360+/profile/resendSecurityEmail)},sendSignUpActivationEmail:function(e){return(new c).get(e)},bindMobile:function(e,t,n){var t=t.areaCode+t.mobileNumber;return(new c({o:user,m:bindMobile,crumb:e,mobile:t,smscode:n},{},!0)).post().done(function(){u()})},signUp:function(t){var n={captchaFlag:!0,captchaApp:e.getConfig(captchaAppId,i360),smDeviceId:i()};t=a.extend(n,t),t.password=r(t.password),t.passwordAgain=r(t.passwordAgain)t.password,o(t,{emailActiveFlag:loginEmailActiveFlag,passwordAgain:rePassword,smsToken:smscode,nickname:nickName,username:userName,agreeLicence:is_agree});var s=new c(t,{},!0);return s.post(s.I360+/reg/doregAccount).done(function(){u()})},signIn:function(t){var n={o:sso,m:login,lm:mobile==t.type?1:0,captFlag:1,rtype:data,validatelm:e.getConfig(signIn.mobile.isMustUseMobileSignIn,!1)?1:0,isKeepAlive:!1,captchaApp:e.getConfig(captchaAppId,i360),userName:t.account,smDeviceId:i()};returnmobile==t.type?t.acctype=2:t.password=r(t.password),a.when().then(function(){return t.tokene.sync.getToken(t.account).done(function(e){t.token=e.token})}).then(function(){return(new c(a.extend(n,t),{},!0)).post().done(function(){u()})}).then(function(t){return e.sync.setCookie(t.s)}).then(function(){return e.getUserInfo(!1)})},signOut:function(t){var n=e.getConfig(supportHttps,l),r=https==e.getConfig(protocol,null).toLowerCase();void 0===t!0===t?t=e.getConfig(domainList,[]):a.isArray(t)(t=[t]);var i,s=[];return a.each(t,function(e,t){a.inArray(t,n)>

　　-1?(s=new c({o:sso,m:setcookie,s:t},{jsonp:func},!0),o.push(s.get(s.getDomainApi(n)))):i(s=new c({o:sso,m:setcookie,s:t},{jsonp:func}),o.push(s.get(s.getDomainApi(n))))}),a.when.apply(a,o)},sendSmsTokenNeedPhrase:function(e,t,n,r,i,s){var o=;returnboolean==typeof e&&(n=t,t=e,r=n,i=r,e=null),login==s?o=0:reg==s&&(o=2),(new c({o:User,m:sendSmsCodeNew,condition:t?1:2,account:n,crumb:e,sms_scene:o,captcha:r,vt:i})).post()},sendSmsToken:function(e,t,n,r){var i=;returnboolean==typeof e&&(n=t,t=e,e=null),object==typeof n&&(n=n.areaCode+n.mobileNumber),findpwd==r&&(i=1),(new c({o:User,m:sendSmsCode,condition:t?1:2,account:n,crumb:e,sms_scene:i})).post()},sendEmailToken:function(e,t){return(new c({o:User,m:sendEmsCode,condition:1,crumb:e,vtype:t})).post()},sendActivationEmail:function(e){var t=new c({crumb:e});return t.post(t.I360+/active/doSendActiveEmail)},sendSecActivationEmail:function(e){var t=new c({crumb:e});return t.post(t.I360+/profile/resendSecurityEmail)},sendSignUpActivationEmail:function(e){return(new c).get(e)},bindMobile:function(e,t,n){var t=t.areaCode+t.mobileNumber;return(new c({o:user,m:bindMobile,crumb:e,mobile:t,smscode:n},{},!0)).post().done(function(){u()})},signUp:function(t){var n={captchaFlag:!0,captchaApp:e.getConfig(captchaAppId,i360),smDeviceId:i()};t=a.extend(n,t),t.password=r(t.password),t.passwordAgain=r(t.passwordAgain)t.password,o(t,{emailActiveFlag:loginEmailActiveFlag,passwordAgain:rePassword,smsToken:smscode,nickname:nickName,username:userName,agreeLicence:is_agree});var s=new c(t,{},!0);return s.post(s.I360+/reg/doregAccount).done(function(){u()})},signIn:function(t){var n={o:sso,m:login,lm:mobile==t.type?1:0,captFlag:1,rtype:data,validatelm:e.getConfig(signIn.mobile.isMustUseMobileSignIn,!1)?1:0,isKeepAlive:!1,captchaApp:e.getConfig(captchaAppId,i360),userName:t.account,smDeviceId:i()};returnmobile==t.type?t.acctype=2:t.password=r(t.password),a.when().then(function(){return t.tokene.sync.getToken(t.account).done(function(e){t.token=e.token})}).then(function(){return(new c(a.extend(n,t),{},!0)).post().done(function(){u()})}).then(function(t){return e.sync.setCookie(t.s)}).then(function(){return e.getUserInfo(!1)})},signOut:function(t){var n=e.getConfig(supportHttps,l),r=https==e.getConfig(protocol,null).toLowerCase();void 0===t!0===t?t=e.getConfig(domainList,[]):a.isArray(t)(t=[t]);var i,s=[];return a.each(t,function(e,t){a.inArray(t,n)-1?(i=new c({o:sso,m:logout},{jsonp:func},!0),s.push(i.get(i.getDomainApi(t)))):r(i=new c({o:sso,m:logout},{jsonp:func}),s.push(i.get(i.getDomainApi(t))))}),u(),a.when.apply(a,s)},fillProfile:function(e,t,n,i,s){return i=in,(new c({o:User,m:perfectInfo,crumb:e,userName:t,captcha:s,password:r(n),rePassword:r(i)},{},!0)).post().done(function(){u()})},perfectMobile:function(e,t,n,i){return(new c({o:user,m:perfectMobile,crumb:e,mobile:t,password:r(n),rePassword:r(n),smscode:i},{})).post()},checkQrCodeSignInStatus:function(){return(new c({o:sso,m:qrLogin},{jsonp:func})).get()},getAuthenticationStatus:function(e){return(new c({o:User,m:getShiMingStatus,crumb:e})).get()},submitAuthenMobile:function(e,t,n){return(new c({o:User,m:verifyShiMingCaptcha,mobile:e,captcha:t,crumb:n},{},!0)).post()},fillAuthenInfo:function(e,t,n){return(new c({o:User,m:verifyShiMingSmsCode,vt:e,vc:t,crumb:n},{},!0)).post()},authSendSmsToken:function(e,t){return(new c({o:User,m:sendShiMingSmsCode,crumb:e,vt:t},{},!0)).post()}};var p={};a.each(e.sync,function(t,n){var r=function(){var r=arguments[0],i=t+(a.isPlainObject(r)?e.utils.JSON.stringify(r):[].join.apply(arguments)),s=p[i];return s?p[i]:(s=p[i]=n.apply(e.sync,arguments),s.always(function(){delete p[i]}),s)};r.funcName=n.funcName=sync.+t,e.sync[t]=r})}(QHPass),function(e){use strict;var t=e.$,n={charset:document.charsetdocument.defaultCharsetdocument.characterSetUTF-8,domainList:[360pay.cn,so.com,haosou.com,360.cn,360.com,qiku.com,360shouji.com],protocol:location.protocol.replace(:,),proxy:location.protocol+//+location.host+/psp_jump.html,ignoreCookie:!1};e.getConfig=function(e,r){r=void 0!==r?r:null;for(var i,s=n,o=e.split(.);o.length>

　　-1?(i=new c({o:sso,m:logout},{jsonp:func},!0),s.push(i.get(i.getDomainApi(t)))):r(i=new c({o:sso,m:logout},{jsonp:func}),s.push(i.get(i.getDomainApi(t))))}),u(),a.when.apply(a,s)},fillProfile:function(e,t,n,i,s){return i=in,(new c({o:User,m:perfectInfo,crumb:e,userName:t,captcha:s,password:r(n),rePassword:r(i)},{},!0)).post().done(function(){u()})},perfectMobile:function(e,t,n,i){return(new c({o:user,m:perfectMobile,crumb:e,mobile:t,password:r(n),rePassword:r(n),smscode:i},{})).post()},checkQrCodeSignInStatus:function(){return(new c({o:sso,m:qrLogin},{jsonp:func})).get()},getAuthenticationStatus:function(e){return(new c({o:User,m:getShiMingStatus,crumb:e})).get()},submitAuthenMobile:function(e,t,n){return(new c({o:User,m:verifyShiMingCaptcha,mobile:e,captcha:t,crumb:n},{},!0)).post()},fillAuthenInfo:function(e,t,n){return(new c({o:User,m:verifyShiMingSmsCode,vt:e,vc:t,crumb:n},{},!0)).post()},authSendSmsToken:function(e,t){return(new c({o:User,m:sendShiMingSmsCode,crumb:e,vt:t},{},!0)).post()}};var p={};a.each(e.sync,function(t,n){var r=function(){var r=arguments[0],i=t+(a.isPlainObject(r)?e.utils.JSON.stringify(r):[].join.apply(arguments)),s=p[i];return s?p[i]:(s=p[i]=n.apply(e.sync,arguments),s.always(function(){delete p[i]}),s)};r.funcName=n.funcName=sync.+t,e.sync[t]=r})}(QHPass),function(e){use strict;var t=e.$,n={charset:document.charsetdocument.defaultCharsetdocument.characterSetUTF-8,domainList:[360pay.cn,so.com,haosou.com,360.cn,360.com,qiku.com,360shouji.com],protocol:location.protocol.replace(:,),proxy:location.protocol+//+location.host+/psp_jump.html,ignoreCookie:!1};e.getConfig=function(e,r){r=void 0!==r?r:null;for(var i,s=n,o=e.split(.);o.length0;)if(i=o.shift(),0!=i.length){if(voi

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